The first Koontz book I read was From The Corner of His Eye and it blew me out of the water.
For years I've read aloud to my wife for an hour or two before bed. That book was terribly fun to read out loud. It just flows off the tongue. It prompted me to buy or borrow everything else by him I could get my hands on, and they're all easy to read that way. I have trouble following many books if I read them aloud, because I read much faster than I speak, and the speed difference throws my brain into a loop of some sort. Something about Koontz's moody writing forces me to slow down my eyes, just to soak in the atmosphere.
Corner is still my favorite, but maybe that's because it was my first. I was excited about Odd Thomas because I'd sort of hoped the title referred to Det. Thomas Vanadium, who was decidedly odd, from Corner. It doesn't, of course, but it's still a darned good book.
Koontz has a few niggly habits that drive me a bit crazy after seeing them too many times (insert dog, chuffing at bougainvillea in the preternatural darkness, here), but of all the Big Names out there he is by far my favorite.
Has anybody read the Frankenstein book yet? I haven't, and I'm sort of put off by the idea of him doing a series. I have no idea why that might be.