Do US agents take spanish written novels for representation?

I don't imagine they'd publish it in Spanish. They'd probably publish it in English and then, if it was popular enough, they might do a version in a different language.

Has the novel already been published in Mexico (I'm presuming, based on your location)? How well did it do there?

That makes a big difference. Best-sellers from other countries are constantly published in translation; less commercial properties are harder to place.

As for novels published in Spanish in the Western Hemisphere, my experience from my librarian days is that US libraries acquire directly from publishers in Mexico and Central and South America at the Guadalajara Book Fair. I think that the US distributors like Ingram and Baker and Taylor do the same, though I'm not sure.

The Spanish-language publishers I'm aware of in the US are focused on fairly narrow market niches, like textbooks and self-help/health.

Hi, there.

I'm just going to give a friendly nudge and mention this is the third time in the third different area I've seen you've posted a variation on this topic. Maybe a mod can merge them together?