It's not a major road, but state highway 49 (in Tennessee, it has another number when it crosses into Kentucky) is the road through the Land Between the Lakes area. LBL is about as big as a national park, but is owned by TVA. There are things like a 1950 farm with people dressed in period costumes, but mostly it's just the scenery.
It's a quiet and scenic road for the most part, except during the height of the tourist season, and even then it's not crowded. Kentucky Lake is on one side, and Lake Barkley is on the other. We used to visit the area a lot when I was a kid. I grew up about an hour's drive from there.