This is diverging a bit - but I travel blue highways every day and sometimes take the longer route to be able to do so. Friday, I had to go two places and could have taken interstate by-pass routes to get to them and between them and then home. Instead, I took the old roads we used before the interstates went in and it was like seeing old friends - the windy road along the creek that developed from a trail 200 years ago, the road that had been the main road through an old part of town (with houses along it going back to at least the 1850's), the road that passes the old, original airport terminal - now looking not much bigger than some of the biggest houses built in the last ten years, but full of memories of watching two engine commercial planes come in to land back in the 50's. Nostalgia, history, and blue highways are everywhere and they don't necessarily have to have been significant in the development of the US (although I was flirting with Route 40 all along my route).
That said, I will add another blue highway - the old stage road from Boston to Albany which in part is route 43 - some beautiful old houses along it and Hancock Shaker Village. Puma