Although the list is meant to poke fun at the conventions of high fantasy, I think a lot of the suggestions, if followed with moderation, can make for an interesting story. You don't have to follow every suggestion, but doing so doesn't make you a hack.
1) Loser MC -- this makes a lot of sense. Flawed characters tend to be more interesting than perfect ones, probably because screwing up leads to more interesting situations.
2) Quest -- okay, so maybe it doesn't have to be the fate of the world, but the fate of SOMETHING better depend on your protagonist's actions, or no one will care what he does.
3) Motley Companions -- this is just my personal opinion, but stories in which the main character interacts with other characters seem more interesting than those in which the main character sits in a box and ponders the meaning of life. Again, just a generalization.
4) Skipping ahead a bit here ... everyone dies. Well, it works for George R. R. Martin. I guess pulling on heartstrings is part of what writers are supposed to do, though sometimes there are worse things you can do to your characters than kill them.