If you're a furry comic, I recommend "Sofawolf Press." They're the biggest of the furry small presses, and they've just gotten into comic books (by virtue of publishing mine!) I think their submission guidelines may be on-line--not sure, I went kinda sideways, since I knew 'em already.
Regardless of genre, if you're interested in the webcomic scene, by the way, I recommend it highly. That was my route--did a webcomic, got a fanbase, had a small press pick it up, got an agent based on it, and now there's all kinds 'o potential craziness in the works. There are tons and tons of webcomics out there--scads--mountains--but the vast majority are dreadful and die quickly. If you can sustain a good and interesting webcomic, it's extremely possible to build up a fairly solid fan base, and there's an increasing number of small presses who are very interested in publishing print collections of successful webcomics.
It's a slow process. You have to keep doing it, and it takes a lot of discipline--every hiatus and every gap. You will not make money for awhile, if ever. But there's a huge, thriving, vibrant webcomics community that is very, very accepting of new talent, and I can't speak highly enough about 'em.
'Course, I'm biased. *grin*