Yes, the variation in skull thickness is amazing. There was a skull in our lab in college that had to be half an inch thick. Solid, no sinus cavities. The guy in college headbutt anyone or anything.
Variation aside, the occipital bone, the one where the spinal column enters the base of the skull, has one of the thickest protuberances (thickened bumps of bone) in the entire body. This 'bump' is where the muscles on the back of the neck attach to the skull. When a body is cremated or eroded away by the elements and time, this is the portion of the skeleton that survives. This portion of the base of the skull might withstand incredible injury but, look at what's just below it: the fragile neck bones, spinal cord, and the base of the brain.
Of course we always expect the perfect blow or the worst case. Then, when we play the villian, it seems everyone has Achilles armor and a patched up heel. Each blow seems misplaced. We can't find our footing and our victim moves or wriggles or falls out of the way. Then, when we connect, the injury always seems worse than it really is. Our victim recovers unexpectedly.