When the characters fall madly and vastly in love despite having nothing in common, no reason for it, and seem to do it only to suffer. These characters are so wrong for one another it's nightmare inducing, and they state it a hundred times, and it doesn't matter because they are so in love (honey, maybe you mean lust?).
Not nothing like he's rich, she's poor, but they both like Mike and Ikes and enjoy a good horror movie. Nothing as in they don't eat the same foods, or have the same values, or have anything they enjoy doing together, and there's possibly whole centuries between his idea of good and hers. The only thing they share is suffering and being in love.
I can think of more than one book like this, where the whole drama is paranormal boy, normal girl, but there's no reason the two should have any connection at all, and beyond their instant, stalker-ish, creepy love (lust?) the two never stop to have fun, or to have a conversation about something they have in common, or to dwell on even one little thing the other person does that they would die if they could never see again.
That's my biggest YA pet peeve, right now, hands-down. And yeah, it mostly relates to vampires and fae, because the werewolves and witches/wizards tend to be more human. But it also relates to some straight-up teen drama, too.