I write literary fiction (sometimes with a dash of SF), and the range of submission options is daunting. Most of the mags I actually read have 0% or 1% acceptances listed on Duotrope. (I'm not just talking McSweeney's, but every university-based lit magazine of much repute.)
So this is an ongoing problem for me. I'll continue to submit to the tough ones, because occasionally (and I mean infrequently), I get a rejection with encouragement. But my only acceptance came from a small print magazine with an 11% acceptance rate on Duotrope. So there is something to those ratings... if you can get past the fact that you might still get rejected and feel worse than you would if the journal were more selective.
Which you shouldn't, because an 11% acceptance rate isn't exactly high. At least, it wasn't when I was applying to college and that was the rate for Harvard...
But I'd appreciate any recs on a sort of mid-level magazine, one that isn't a household name (like McSweeney's) and isn't primarily seeking work by already well-published novelists and academic writing teachers looking to get tenure (like, say, The New England Review).