Abbreviation with commas?

JJM said:

How do you treat a comma if it needs to be situated just behind a period being used to abbreviate, example:
Mr(./,) will you help? My brother won't give me some of his birthday cake."
Do I keep the period and toss the comma, vice-versa, un-abbreviate, or keep them both? :O

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In dialogue, I'd probably spell it out, especially because it's not Mr. Somebody. So: "Mister, will you help?"

Alternatively, if you absolutely MUST keep the abbreviation, I'd keep the period (I'm a North American writer; UK writers would have a different view because they don't use punctuation with addresses). So: "Mr., will you help?"

The first example, however, looks better to me.

I wouldn't use the abbreviation at all in this case. Mr is an abbreviated title, like Col or Gen. There's no occasion where you'd write Somebody get me a Dr.

Which leaves the strange case of Mrs to deal with, which can't really be written out in full.

There's Hey Misses (plain wrong), Hey Missus (Dodie Smith's dog) or Hey Mrs. I'd probably go without the full stop if there was going to be a comma, but it still looks quite strange.