I've been thinking about this recently because I've read several epic fantasies where multiple POVs are common. One thing you might do is establish a hierarchy of POVs, so that if POV character #1 and #2 are together, we always see that scene from #1's POV, for instance. That orients the reader to who the primary character is.
However, I think the really important thing to remember is that readers want two things: they want to care about the characters and they want a story that's more unified and coherent than life. POV helps a writer with the first thing but needs to be handled carefully to achieve the second.
POV is more than a way to have eyes in different parts of the landscape. It's a way to encourage the reader to identify with the character, to see things as the character does and understand that character. This was driven home to me when I read Guy Gavriel Kay's The Last Light of the Sun, which adapts the history of Alfred the Great's battle against Viking invaders. Kay has tons of POVs, and I have to admit there were moments when I wished he'd not gone on for those three pages about that woman by the side of the road whom we never see again.
But there's this one scene that I thought was just brilliant. King Aeldred captures a group of Viking mercenaries, and we see this encounter mostly from the POV of one of the men in Aeldred's force, though we also get a glimpse into the head of the Viking leader. The king is incensed not only over the invasion, and the threat the Vikings will prove to another part of the kingdom if their ships get away, but also on a more personal level because the Vikings earlier caught six of Aeldred's men, a patrol led by his best friend. Rather than hold the captives for hostage, which is what everyone would expect, the Vikings killed them all in a scene we saw. And because we saw it, we know that the Viking mercenaries were appalled by the killings because they cost them money. Only the man who hired them wanted the hostages dead, so he killed Aeldred's friend and started the fight. That killer has already escaped.
Btw, the invaders are not people you'd want in your neighborhood. They're not only Vikings. They're mercenaries. And their leader has very bad plans for the place they're headed next. The POV character in Aeldred's group is attached to the people in that next place, so we sympathize with Aeldred's need for information.
Aeldred starts by ordering his son, who's maybe 20 and leading the archers, to shoot 6 of the Vikings because they killed the 6 men in the patrol. Bam. They're dead. Then he asks where the ships are. The Vikings refuse to betray their fellow mercenaries. Aeldred says kill 10 more. Bam. And we know, which Aeldred doesn't, that one of the dead men this time is a friend of the Viking leader, so now he's really not going to give the information Aeldred wants.
I have to say, I'm usually bored by battle scenes but this whole scene was riveting to me, partly because a sympathetically presented, autocratic king is not something I understand very well. But also, because we'd seen both sides of this encounter ahead of time, my sympathies were with all of them, and the horror of the scene was heightened.
That's a terrific use for multiple POV.
In contrast, I read another epic fantasy recently where the plot lines didn't seem to connect at all. I loved one POV character and was indifferent to the others. Eventually I stopped reading the parts not about the character I liked, and it turned out not to matter one bit to the story I wound up reading. That's a problem. That book felt fragmented by the multiple POVs, which didn't cluster around a central plot line.