It's a harder question than it sounds, because each writer has different issues that need to be worked through. And not only that, each book might be different from the last. For example, I always run short, so one part of that stage for me is to add material. I have to add subplots and work on expanding scenes to make word count. Other people have to take a weed whacker to their novel, getting rid of unnecessary subplots and shortening scenes.
Some suggestions:
Let the story sit for six weeks or at least a month. Some problems will jump out at you because the book will look different.
As mentioned, get a crit of the first chapter. Any problems the critters point out are likely to be in the rest of the book. But you should also do many, many crits yourself. That'll show you how to revise more than anything else because you'll see a problem in someone's piece and suddenly realize, "I did that, too."
Read the Learn Writing with Uncle Jim thread:
http://absolutewrite.com/forums/showthread.php?t=6710