Hasn't seemed to bother Harper Lee or Margaret Mitchell, among others.
I think Margaret Mitchell had more than one book.
(from Wikipedia, that font of fun...)
"For decades it was thought that Mitchell had only ever written one complete novel. (In fact, periodically claims are made that she never wrote it at all due to the lack of any other published work by her). But in the 1990s, a manuscript by Mitchell of a
novel entitled
Lost Laysen was discovered among a collection of letters Mitchell had given in the early 1920s to a suitor named
Henry Love Angel. The manuscript had been written in two notebooks in 1916. In the 1990s, Angel's son discovered the manuscript and sent it to the Road to Tara Museum, which authenticated the work. A special edition of
Lost Laysen — a romance set in the
South Pacific — was edited by
Debra Freer, augmented with an account of Mitchell and Angel's romance including a number of her letters to him, and published by the Scribner imprint of
Simon & Schuster in 1996."
Not to mention, she wrote biographies of prominent Civil war generals, articles, etc.
And...she never sought publication for Gone With the Wind.
(adding a bit about Harper Lee from Wiki too)
"Since publication of To Kill a Mockingbird, Lee has granted almost no requests for interviews or public appearances, and with the exception of a few short essays, has published no further writings. She did work on a second novel for years, eventually filing it away unpublished.[citation needed] During the mid-1980s, she began a book of nonfiction about an Alabama serial murderer, but she put it aside when she was not satisfied.[citation needed] Her withdrawal from public life prompted unfounded speculation that new publications were in the works. Similar speculation followed the American writers J. D. Salinger and Ralph Ellison."
Just because an author got one book published doesn't mean they stopped writing.
I'll caveat this with the over generalization that Fiction writers will write more than one story. If the first doesn't sell, keep plugging away at getting it to sell, but write the next one...
Amy