Short answer-no. A contusion is a bruise. Lasers are focused light. Light will not bruise you.
You may be thinking of a concussion, which is what happens to your brain after a blow to the head.
That said, light CAN hurt you. Lasers can burn you or blind you. Other types of focused radiation beams can damage brain tissue or cause cancer (wiki gamma knife radiotherapy for example). So you could permanently damage someone's brain that way. For a physical brain injury, you just can't beat a good hard crack on the noggin, though.