Yes, Kate Stewart! For that matter, her father, who started out a bit ambivalent about the Doctor, just for being a rather odd civilian. Sadly, he is no longer with us.
Or, the Rani, who was only in a couple of episodes, so new territory, so to speak. And, then she was a female, facing off against male Timelords - the Doctor and the Master. Maybe now she's a male? Or, light and dark, the Time Lords meet.
For that matter, the Master is
supposed to be dead, in the same way that the Doctor was
supposed to have only a set number of regenerations.
Life will find a way. - Sorry, wrong franchise.