I'm finishing my third non-fiction book to be self published soon. I spent most of the day doing some polishing on my manuscript and then doing a bit of layout on my desktop publishing computer. I use Scrivener to compose my manuscript and compile and organize research etc., then I transfer the manuscript into Scribus to physically compose it into book form suitable for printing. It works, but it is also somewhat cumbersome.

For those who self publish what is your preferred method? I would very much appreciate any tips or advice. Thanks!