The discovery that apparently dead cells can sometimes resurrect themselves has researchers exploring how far they can push the point of no return.
Quanta Magazine said:“When cells are no longer needed, they die with what can only be called great dignity,” Bill Bryson wrote in A Short History of Nearly Everything. The received wisdom has long been that this march toward oblivion, once sufficiently advanced, cannot be reversed. But as science charts the contours of cellular function in ever-greater detail, a more fluid conception of cellular life and death has begun to gain the upper hand.
Perhaps the most dramatic proof of this emerged last April, when a team at the Yale School of Medicine drew global attention for briefly restoring cellular activity in dead brains. The neuroscientists Nenad Sestan, Zvonimir Vrselja and their colleagues developed a system called BrainEx that can perfuse a brain with a hemoglobin-based solution to nourish cells while promoting their recovery from oxygen deprivation, a condition that is usually lethal for neurons after 10 minutes or so. They tested it on brains extracted from slaughtered pigs, deprived of blood and kept at room temperature for as long as four hours — making them quite thoroughly dead by any conventional standard.
Yet after being perfused with the experimental solution for six hours, many of those deteriorating and seemingly lifeless brain cells regained — at least temporarily — some of their normal structure and metabolic activity. Slices of neural tissue were even able to conduct electrical signals (for ethical reasons, the researchers had generally suppressed that capacity in the animals’ whole brains). BrainEx or something like it might someday be used to restore brains threatened by strokes, oxygen deprivation or other conditions, although years of further testing will be needed before that’s possible.
The Yale team’s achievement headlined a spate of recent work that probes the liminal space between cellular life and death. Although life and death are commonly treated as alternatives, it’s not that simple. Physicians, medical ethicists and lawmakers have struggled to define the moment of death for humans: Is it when breathing ceases? When the heart stops beating? When brain activity is undetectable? Different answers arise because death is a process, and not necessarily an irreversible one.
The barrier between life and death is porous even at the level of cells, the fundamental units of life. Researchers are learning that cells once thought terminal or dead can resurrect themselves, or be partially resurrected, under the right conditions. By studying the processes that allow cells in limbo to inch back toward life, scientists ultimately hope to restore diseased cells to health, limit overactive cell division, resuscitate expired organs and even pave the way for long-extinct creatures to roam again.
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