I don't really notice much profanity, unless it's constant, so either I don't give a damn, or there isn't much of it on regular cable? TV.
Where are you planning to sell this? That's probably the big question.
How do other shows like yours, or at least other sexy, druggy, gorey shows do it?
'Supernatural', 'Breaking Bad', etc. ? I hear 'Deadwood' was well-known for swearing and cursing. But, once the novelty's gone, it loses it's shock value and then, what's the point?
If you don't like profanity, don't use it. When is it 'necessary'? It's a word choice like everything else. As someone else said upthread, though, don't make-up swears and profanity. Unless the character is trying not to swear in front of Grandma. Then, it's the character who's making up 'profanity'. Otherwise, you're just drawing attention to it.