A few months ago I sent a manuscript to some agents. I never recieved a reply from either and I'm curious should I continue patiently waiting for a reply, or should I forget about them and continue sending queries and such out?

So I don't have to start another topic about it:

I sent the manuscript mentioned above to some publishing houses(2 of which replied with rejection), and I'm curious which route I should pursue more agents or publishing houses?

Any bit of help with these two matters would be highly appreciated.