When I roll my eyes, it's usually straight upward toward the heavens seeking guidance before I say something I will surely regret. That short pause often keeps me out of trouble.
At other times, when some blowhard is espousing this, that or the other thing, I might glance in the direction of another unfortunate audience member and roll my eyes as a signal that the person doing the espousing is full of all sorts of crap and is not to be believed. The response is either a knowing grin or an exaggerated eye roll that lets me know we're on the same page regarding said character.
The most pathetic and withering eye roll I can imagine comes from someone I love who uses the gesture to let me know that my well planned and choreographed advances have about as much chance at succeeding as a snow ball in hell knocking Lucifer unconscious. But it doesn't keep me from trying!