Not in this novel, because I couldn't do it the way I wanted. In order for a first time writer to get published, from everything I have read, I need to both keep the novel self-contained and within a rather small word-count. Even with cutting thing way back I am at 130,000 words.
I think you're going to find it virtually impossible to get a first novel of that length even looked at by an agent. I would recommend you think about splitting it into two novels. Not necessarily by just ending a first novel halfway through the manuscript, but by moving storylines to set up two different complete stories. I wish you luck, because it won't be easy.
Don't make that decision on my input, however, because I still can't seem to land my own agent. See if you can get a couple more opinions in these forums.