I have an editor who says that if someone was stabbed in the chest with a thin, sharp instrument, there's only a one in a million chance that the person doing the stabbing would hit the heart and kill the person.
Your editor has never been in a knife fight, or treated members of the Saturday Night Knife and Gun Club.
1 - Define "chest". If you want to make sure to hit the heart, stab right under the sternum and aim slightly upwards and directly towards the spine... you nail it every time.
2 - You don't have to hit the heart ... all you have to do is hit a big-enough blood vessel (artery or vein) and they'll drown in their own blood. Going straight in on the midline just below the sternum, and deep, if you miss the heart, you have a good chance of hitting the descending aorta OR the vena cava.
3 - The most dangerous stab wounds are right around the nipple level aimed at the spine because you have not only the heart, aorta, and vena cava, but the pulmonary arteries to hit.
4 - Stabs from the rear are less likely to be fatal because the aorta and vena cava are partly protected by the spine. And the shoulder blades get in the way. You can, however, stab upwards just to one side of the spine, just below the ribs and take out a kidney and the renal artery. It's also a major bleeder.
5 - Stab wounds to the lungs can be slowly fatal because the wound lets air into the pleural cavity, the lung collapses and bad things happen (see tension pneumothorax and traumatic pneumothorax)
With a random stab at a moving target the chances are good you'll hit a rib and the knife is deflected. It may be deflected towards or away from blood vessels.
The stereotypical dagger wielding maniac waving the thing to stab downward is less dangerous than the maniac who is holding the blade low to strike upwards. Fewer bones and more soft things that bleed.