Would you query an agent who may be a good fit for your current book, but not for your future projects? She stated no high fantasy, but the next series I plan to work on is high fantasy.
Nope. It's one thing if an agent has favorite genres and you think you might sometime write something other than one of those favorites, and a different thing if they don't rep something you want to write.
FREX: My agent doesn't rep much horror because his contacts in that genre are not as strong as the other genres he reps. When I wrote a trilogy of Southern Gothic/Horror novellas he offered to help however I needed, but encouraged me to take the lead (also because novellas are a different thing than novels) because, after talking he felt like I had a better idea of where to send the query on the project.
But if an agent says "I don't want X" they will not be a good fit for you. It could be it's not a genre they read or like. It could be a genre they have no contacts for. But if they are explicitly saying "Don't send this" it's unlikely they would change their mind later just because they had repped something else for you.
Some agents will refer clients with material they don't represent to another agent at the same agency. Sometimes you can get a second agent at a different agency for a different genre, but that's tricky, especially if they are at all related. (Urban Fantasy and High Fantasy, for instance, where there might be some overlap between editors/publishers being queried.) And it can potentially require a lot of work on the part of the author to make certain that both agents are co-ordinated enough when it comes to publishing different books within the same time frame. (Doesn't mean it can't be done, because folks do it. Just that it's not what I would consider ideal.)