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View Full Version : I need a biochemist ....



Dollywagon
06-16-2014, 08:55 PM
to go over the sequencing relative to a metabolic pathway and assist in deciphering how disruptions to that pathway would manifest in physical symptoms.
Please.

jennontheisland
06-16-2014, 09:02 PM
Which pathway, what symptoms?

Dollywagon
06-16-2014, 09:11 PM
Cobalamin.
Methionine synthase and Methylmalonyl CoA

I know what symptoms arise but I don't know the chronological sequence. For instance with the Methionine which is the homocysteine conversion - you can get heart attacks as homocysteine builds up, you can get DNA cellular dysfunction, and you can get anaemia. But in which order?

Sorry if I disappear for a while but I'm dying my hair and I'd like it not to be pink when it's done...

jennontheisland
06-16-2014, 09:31 PM
I would bet that it's a fair assumption to think that that heart attack is the last thing that happens. If you're sure you need this level of detail for the story, I recommend a university journal database.

I found this article by googling phrases in your post:
http://jn.nutrition.org/content/136/6/1722S.full

Check the reference list for things that may be of more use.

Dollywagon
06-16-2014, 09:48 PM
Many thanks.

I haven't got pink hair to worry about so I'll take time to browse the site.