I have a scene where two characters retreat to an empty general goods store, being chased by a humanoid creature. I've been trying to think the scene over and over and over because I need them to have no option but to retreat through a magical doorway created in the store. So I have been wondering if it would be possible to create a kind of incendiary device very quickly from materials in a general goods store that would do enough damage to destroy the monster - or at least damage it enough that DNA evidence was a moot point (or at least too expensive to be a viable option, or damaged enough to delay humans looking at the remains too closely before they were disappeared) - and also is enough damage that the two characters have no way to escape the blast without opening up the magic doorway.
Anyone smarter than me who might know what they would use or do in the grocery store to do this?
This would be the sort of thing I could probably get locked up for even knowing over here in CCTV UK, so I don't actually have any ideas for you. But I would say you would have to attribute that kind of knowledge to a character anyway, so there's no burning need to share the details with the reader.
You could just have your MacGyver grab a bunch of cleaning supplies and send the POV character to watch the door. When we next look back, there's a bubbling bucket of chemicals and a fuse of some kind. Dramatic escape! Explosion! And scene. You can hide the actual chemistry in the direction and if you've done the groundwork with the character in question it should work fine.
In fact this kind of scene is generally used to do character work. Have you seen Under Siege, with beefy zen-bro Steven Seagal as a Navy cook? There's a bit where the mercenary killers are coming to kill him in his kitchen and we don't quite know the extent of his martial powers as yet - we know nothing of his background either. He rigs up some kind of IED using the microwave oven as a timer. We have no real idea what this consists of - the director and editor just have Seagal swiftly and decisively slap something together, whack it in the oven and get out of there. The character point is: Seagal is surprisingly swift, decisive, ingenious and deadly for a cook.