Eh, I wouldn't quite equate House of Leaves with what the OP is suggesting. I mean, okay, the passages are written upside and backwards and side-to-side and there are pages and pages of footnotes and appendices so you have to flip it back and forth and spin it around in a circle to read it, period. But nowhere in the text does it say, "Please stand on your head and recite the National Anthem before reading the next chapter." It's not quite that direct.
To the OP: I'd have to see it in context, honestly. I can see the humor angle as a possibility, and also the experimental angle, and also the children's/middle grade angle, but without knowing what you're actually going for, it's hard to say.
Personally, I resent being told explicitly what to do, by anyone, and that includes books. I'm just stubborn that way.