Commas, for sure.
Maryn, sure*
*Hmm, can I work sure in there one more time? Sure!
Edited to add: A really good answer wouldn't just say but would explain why. So you've got this sentence, Even Hank, son of John, could see she was upset. The words son of John rename the noun immediately before, Hank. That makes it an appositive phrase, a noun or noun substitute that, together with what it modifies, renames the last noun.
Appositives can be either nonrestrictive or restrictive. Huh? Yeah, lots of big words, but it's not as hard as it sounds. An appositive is a renaming word or phrase. Call it renamer in your mind if it helps.
A nonrestrictive appositive simply renames some noun (often a person) when we know who or what it is. The appositive gives more information, but we don't need it to know who or what the author's talking about. Nonrestrictive appositives are set off with commas. Examples: My only neighbor for miles, Farmer Bob, grows beets. (Nonrestrictive because there's only one person who's the only neighbor for miles.) The assigned novel, Catch-22, was hilarious. (Nonrestrictive because there's only one assigned novel mentioned.)
A restrictive appositive is essential to identify the noun it follows. Without that renaming, the reader can't tell exactly who or what the author is referring to. Restrictive appositives are not set off with commas. Examples: Gold-medal gymnast Erich Schmidt retired in 2009. (Restrictive because there are many gold-medal gymnasts.) Bruce Springsteen's hit "Born to Run" became an anthem for misfits. (Restrictive because Springsteen has had many hit songs.)