Thank you all for your responses. I certainly make every effort to double check what specific agents in the same firm say about what they are interested in reading. I do have a further complication for my submission. A while back I decided to use a professional editor to help me 'polish' my manuscript. During our conversations, I asked what she felt was the correct genre to use when describing my work. She told me that she felt that it could fall into both the action/adventure area and the thriller/mystery genre. I've queried agents who specify either or both. I hesitate to say this but, if I had to compare my fiction to anything, I'd have to say it has elements similar to Dan Brown's 'The Da Vinci Code'. While I make an effort to play this down in my query letter, it is difficult to do this in my synopsis. Obviously, I have no way to know if this similarity is having a negative impact on prospective agents. All that being said, going back to my original question - if one agent in a firm specifies action/adventure and another thriller/mystery, and the agency says it is okay to query different agents in their firm, if I get a rejection from one, does it make sense to query the other using the different genre? The vast majority of the rejections I get are form type so I have no idea why I'm getting them. I did get one request for a partial and then for the full, but after seven weeks, got rejected, again with no real explanation. Sorry I'm being so long winded.