Sure. When I was querying Novel 2, some of the first queries I sent were to the agents who had requested partials/fulls of Novel 1. Same with Novel 3.
With Novel 2, I queried an agent who had rejected Novel 1--I don't think she asked for material, but she recommend I try querying Agent X with it. So I queried Agent X with Novel 2, which she asked for the full and then ultimately rejected with some nice comments. When I was putting together my query list for Novel 3, I included Agent X and queried her.
Agent X asked for the full. She ultimately rejected Novel 3, but she said she had a colleague who might be a good fit and could she send it to him? I said yes. He read it and offered representation four days later.
Off the top of my head, I know of at least one other author who eventually signed with an agent who'd rejected previous projects--I just can't think of her name (bad memory!). It happens.