Well, so far, I've submitted to 27 literary agents, got 13 rejections, which is enough to change my gameplan. I'm not discouraged at all by the rejections I've received. In fact, I've had agents encourage me to query widely, wish me all the best in finding an agent as dedicated to my work as much as I am. I've even had one agent say she's passing at her own risk. These agents have all read between five and fifty pages of my book. Yet, I still had one agent who gave me a very negative response. But that one negative response happened to be the 13th rejection, so now I'm going straight to the publishers (not the big ones of course). I'm sticking with the small, medium and emerging presses.
Anyway, to get to my original point, not all rejections are bad. Learn from the positive and the negative, and if you have any agent telling you your writing is crap, or your book is unpublishable, ignore it, thow it in the trash, and keep trying. You've worked so hard to complete your book, so no one has the right to tell you that your work isn't good enough, even if it does need more editing and revision.
If Stephanie Meyer's Twilight sagas can sell millions of copies, and her writing isn't superb (so I heard) so can yours. Remember, it takes the right person to take a chance on you, and it is that person who will make all the difference. I believe it will happen to you, and I believe it will happen to me. Sometimes, though, you have to change your gameplan once, twice or more times before you win the Gold medal.
Good luck
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My personal website
www.deannasonlinewriting.com