Out of approximately 50 queries for my novel, so far I've gotten requests for four fulls and three partials. Two of the fulls were rejected with no explanation, though I chalk it up to agent-genre mismatch as much as anything. Two of the fulls are pending, as are the partials.
I've never used recreational drugs, but I can relate to someone who uses uppers and downers. When your entire ego is on the line, a steady hand on the emotional rudder is in order!