Like askcb said, it depends on what your skills are and whether the intended recipient has any interest in what you can do.
Sewing, knitting, crocheting, tatting, felting, petit point, crewel: It's hard to come up with anything a male would enjoy, except young boys, LARP folks, and re-enactors. Think outside the box a bit, beyond clothing. An apron for woodworking, a do-rag for yard work or biking, a tote strong enough for firewood, a go-bag with pockets for every necessity...
Baking, candy-making: everybody likes home-made bread, cookies, candies, etc., but not everybody can handle the calories, fat content, and such. Plus shipping can present freshness problems. But for those who don't have should-I-eat-this concerns and live nearby, receiving home-made goodies is a lovely treat.
Computer skills: Whether you have genuine expertise or just the willingness to put in some effort, you can probably do something cool. Digitize the family photo album from the recipient's childhood, returning it to whoever owns it fully intact. Rip somebody's entire CD collection, or generate first-rate playlists to their taste. Reformat their hard drive without losing any content--well beyond some people's comfort level, but who doesn't like a computer that runs faster and better?
Woodworking: Even if your skills are no more than basic, most people would like a custom shelf, picture frame, printer table, or other simple item which exactly fits the place it would be used.
Dolls, toys, etc.: Highly individualized, but for the right recipient this can be a lovely gift. The dollmaker in our family has gifted her metal-loving adult brother with a Satan doll and is making him a brain for his birthday. (Shh, don't tell him.)
Maryn, who's getting something from the dollmaker soon, she says
Edit: Sassy, I'd love details on the record-melting