I use ESET Nod32, which is a really effective AntiVirus so far. This is the first time I have experienced a software which hasn't ruined my pc in over a year. (I am using it on my laptop) Like you I also owned a license of McAfee and had the most amount of trouble with it. I also owned Norton at one time, and it was the same. I also had AVG, and had trouble with it eventually. I also had Avast too, and the same thing happened. Sypot Search and Destory ruined my pc too.
These anti virus softwares were used on my desktop pc, which reincarnated about 20 different times within a time span of 8 years. This pc originally was a packard bell, but we re-used all the parts and just got a technician to update the hardrive and import new parts in it over the years. The original computer is actually 13 years old, but that no longer exists since all the parts got replaced with other recycled parts. I did have the packard bell screen for a long while though, and only got a flat LCD screen about 5 or 6 years ago for it.
Overall am happy with this new Anti Virus, and interestingly enough it is also the main Anti Virus Software for the computers where I work.