I'd be wary of using anything involving the heart, even the instant destruction of it still leaves about 5 or six seconds of useful consciousness in which said person may react, there will still be oxygenated blood in their system for a few moments. Whatever attack you use it is it must attack the central nervious system first in order for it to be a quiet death.
Smashing someone on the back of the head can be quite fatal if done hard enough, although there may be a reflexive grunt and of course the body hitting the ground.
Yanking the head forward and shoving a knife into the brain stem brings immediate death and an instant severing of voluntary muscle control.
Poisons pose the same problems as attacking the heart, however potent it may be it still will have to circulate before having any effect, and that will give the victim a chance to fight and maybe scream before that happens.
A surprise strangling of the victim will cut off any chance of making a noise, and if the attacker is strong enough to lift the person off the ground while doing so (looping the weapon around the neck and hoisting them over the shoulder) will minimize their chance of making noise while struggling. Ever see the movie "Hitman?" That's what I'm talking about.
The Vulcan Death Pinch. Quick and quiet.
Ha ha! I wish it were that simple, I would have a lot fewer problems at work!