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Meigner
08-06-2008, 04:55 AM
Continued exposure to what chemical products, medication, gases... can affect a persons short-term memory? I have a story about a man locked in a bedroom so anything that can be put into his food, or released into the air ducts, or a visual stimulation will suffice.

Thanks.

Albedo
08-06-2008, 07:37 AM
The most obvious example is alcohol, but that's probably not what you're after.

Siddow
08-06-2008, 07:50 AM
http://yourtotalhealth.ivillage.com/amnesia.html?pageNum=4

fwiw, I found that page by googling 'chemicals causing amnesia'. Further google anything interesting you find there.

benbradley
08-06-2008, 08:05 AM
I forget the technical/chemical name, but probably the "date rape" drug is what you the character in your story doing this wants.

rugcat
08-06-2008, 08:25 AM
I forget the technical/chemical name, but probably the "date rape" drug is what you the character in your story doing this wants. Rohypnol.

Halcion, a sedative and sleep aid, is also said to sometime produce temporary amnesia -- I've heard dentists sometimes use it in combination with demerol for difficult procedures -- the patient then can't recall how bad the whole thing was.

Jersey Chick
08-06-2008, 09:03 AM
A lot of anesthesia-type drugs cause short-term memory loss - like rugcat said - so you forget how terrible having that root canal or wisdom tooth extraction really was... :)

Meigner
08-06-2008, 03:10 PM
Thanks you guys am likely going to go with Halcion it fits the purpose of the story the most.

Calla Lily
08-06-2008, 04:36 PM
I took Halcion when I had LASIK done on my eyes. It's a mild hallucingen as well. Its effect after about 20 mins was that I no longer wanted to hang screaming from the ceiling--I was kinda, like, dude, I can, y'know, deal. :rolleyes: I presume my dose was quite mild, since I remember the procedure quite well.

RJK
08-06-2008, 05:36 PM
Ketamine can be administered orally or injected intramuscularly. Continued dosage will wipe the person's memory of all events while on the drug. It is a popular 'Date rape' drug. It is my understanding that it can be used long term to keep the person in the state you are talking about.

I'm using it as an integral tool in my current WIP.

GeorgeK
08-06-2008, 07:33 PM
Halcion by itself is normally not an amnestic, but it is often combined with multiple other agents and those combinations have rarely been studied.

Alcohol is the classic, but usually requires long term high dosage when used on its own and will have side effects most likely when the person wakes up. It also can potentiate the effects of other things such that smaller dosages can have more significant effects, but also a higher risk of complications, like apnea, permanent brain damage etc. Anyone remember Karen Ann Quinlan?

Rohypnol (sp?) as said above can have true black outs, where people recognize that there is a gap in their memory and so know that something happened.

Ketamine is more of a dissociative they will probably remember strange distorted images.

Propofol (aka milk of amnesia, but I've only ever seen it give IV) is a classic with little side effects.

Versed (a relative of valium) has been known to cause retrograde amnesia. I often had patients who could not remember what I told them in the pre-op holding area before they were given the versed by the anaesthesia personell prior to going back to the OR.

ColoradoGuy
08-06-2008, 08:51 PM
Ketamine can be administered orally or injected intramuscularly. Continued dosage will wipe the person's memory of all events while on the drug. It is a popular 'Date rape' drug. It is my understanding that it can be used long term to keep the person in the state you are talking about.

I'm using it as an integral tool in my current WIP.
I'd be careful in your scenario about "long term" use of ketamine in doses sufficient to produce altered mental state. I sometimes treat patients for several days with it IV when I don't have anything else that seems to be working, and it invariably causes pretty fast heart rate, often increased blood pressure, and a major increase in salivation and deeper respiratory secretions--they literally foam at the mouth (unless I use other drugs to block that effect). There are studies of long-term oral ketamine as an adjunct to other drugs, but you don't get much in the way of mind-altering effects.

I agree with George about the amnestic effects of benzodiazepines like midazolam (Versed). Fifteen minutes or so of retrograde amnesia is common--they forget what happened even before they got the injection.

rugcat
08-07-2008, 02:16 AM
I agree with George about the amnestic effects of benzodiazepines like midazolam (Versed). Fifteen minutes or so of retrograde amnesia is common--they forget what happened even before they got the injection.I've had small amounts of Versed during procedures and could remember everything. The real question is where can I get some more?

ColoradoGuy
08-07-2008, 04:12 AM
I've had small amounts of Versed during procedures and could remember everything. The real question is where can I get some more?
A big guy like you? Demand 3 milligrams, followed by another 2 or so if you're still coherent after the first dose. 5 mg should do you fine. But you're over 18 so I can't help ya with that.