What is your opinion of ebook versus print?

Have you tried to get an agent to represent you?

Have you made any submissions to traditional publishing houses?

IMHO, of course there are always exceptions, if you print your work as an e-book it will be next to impossible to get it placed with a traditional publisher--unless you are that very, very rare exception.

It depends what book you have and what your goals are. The type of book that does better as an ebook is mainly niche non-fiction, romance and erotica. And that still depends on being accepted by one fo the really top e-presses who are about as selective as a print publisher that would generate the same sales.

Epublishers are generally small presses and small presses are very generally more accessible to new authors. But that in itself is not much of a virtue. The question is what you want for the book (money, sales volume, literary kudos?) and which press that might plausibly accept your work will give you the most of it.

Think about how many ebooks you have bought and read vs. how many actual books. I have never bought or considered buying an ebook. Although I am sure there is a market for ebooks, it is smaller. I would really try traditional publishers first. But even before that, I think you should reconsider getting an agent. With an agent, you will have someone in your corner and better access to publishers. A little warning - good agents are as hard to get as good publishers. Good luck in your search.

Personally if you books is suitable for the mainstream I suggest trying every mainstream press it suits. You can always try medium and small presses later.

And write another book

Why don't you want an agent? As you have found, without an agent it's impossible to get most publishing houses to look at your manuscript. An agent will negotiate your contract, get you the best deal possible, deal with foreign and film rights, guide you with your rewrites, helps you with the next book. So why would you not want one?

There are some large and reputable e-publishers out there that would certainly count as a publishing credit to traditional agents and publishers, and who have a fairly large readership of their own. Some publishers even release their more popular e-books in print (I know Elora's Cave does this). But e-publishing is primarily geared towards romance and erotica (as others have said) and some short or novella length works in other genres (all the large e-publishers I can think of are exclusively romance/romantica/erotica). If you have a full-length novel that isn't romance or erotica, I can't see any of the large e-publishers being interested. You're also talking much less in advance and royalties (a lot of times no advance at all). It is much easier to directly submit to e-publishers than to traditional print publishers, but you have to decide if that's worth taking a great deal less money for your work (you usually won't be able to go with a print publisher later, because they want ALL the rights to your work, not just the print publishing rights). If you do decide to submit to e-book publishers, check them out very thoroughly and make sure they're legitimate and worthwhile.