I've noticed my console game taking longer and longer to load. Level 42 now, and it's a good minute if I'm stepping outdoors.
You know, Dragon Age Origins starts doing the same thing at about 80% completion. Just thought of that. It probably has to load all the different variables for content you've progressed through. Though why DAO would care what dialog options I picked in Lothering when I'm about to conclude the Landsmeet in Denerim is beyond me. In Skyrim it makes some sense, since I could be going back to a de-populated Whiterun after a drunking fireball fest.
Also, has anyone run into stuck NPCs? In Whiterun the produce girl is standing about fifteen feet in front of her shop. She doesn't count as being 'at her store' so I can't buy/sell from her. Had a similar issue with the trader in the open-air stalls in Windhelm, but that seems to have corrected itself.