Maybe it's a sign. My reception with agents has always been lukewarm at best, but the one round of subs I did to pretty high end publishers, two of whom are not even close to being matches in my mind, netted me one who read the whole thing, gave lots of constructive feedback, and seems somewhat receptive to a second viewing. I'm beginning to think I'll have a better chance simply representing myself and approaching all the good publishers who deal in SF&F. It seems to be the best genre if you're going to represent yourself, as there are a half-dozen major imprints who accept author submissions.
So, two more weeks to get my submissions together for the six big SF&F imprints I can submit to, and I'm just going to press ahead, agents be damned.