Is anybody aware of publishers who have an open door to un-agented manuscripts?
You may have heard of authonomy.com It's HarperCollins UK's 'electronic slush pile'. It's a sort of cage match among thousands of authors to reach the top of the heap, where HC 'might' consider your MS.
If nothing else, it's worth exploring as a cross section of what publishers are receiving over the transom these days. Most is, well, slush, but the 2% or 5% that bubbles to the top makes me pause and examine my own writing again.