The book I'm currently planning is an alternate history that does deal with some of the themes you've listed, but I've come to the conclusion that it is probably best suited to the YA market. It simply comes down to a vague feeling the story is giving off to me. I guess you could say tone or voice. The MC is a teen, and there's madness, corruption, and political intrigue, but at the core, it is an adventure story. The heroic, pulpy kind of adventure that I adored when I was younger. I want to write this story for readers with a highly developed sense of wonder.
My most recent book 'Shadow Web' is alt history and included terrorism, sexism, class conflict, a bit of torture and has a vaguely romantic sub plot. It's published as YA mainly because it is written from the POV of a sixteen year old girl and because I am seen as a YA writer.