Many fine publishers use POD to produce their books: Wildside/Prime, Raw Dog, Eraserhead, etc. This does NOT mean they are self-publishing.
Self-publishing means that you pay someone money to print and publish your book. Sometimes it is a vanity-publisher, such as iUniverse or Publish America. Sometimes it is a printing company, such as Cafe Press or Lulu.com. In any case, YOU PAID MONEY TO GET IT OUT THERE, RATHER THAN THEM PAYING YOU FOR THE RIGHT TO PUBLISH IT. It's that simple, really. It has nothing to do with POD, other than the fact that most vanity presses (publishers who make a living enabling authors to self-publish) use POD technology.
Are we clear? Do you understand the difference between Raw Dog and iUniverse or Wildside and Lulu.com? I hope so, because I grow weary of explaining it every few months. In a nutshell: Eraserhead good. Publish America bad.