I've read that many agents get several dozen queries a week, though I came across one agent who got as many as a couple of hundred.
I wonder what this means in terms of the time spent on each query, on average? Or is an average a meaningful measure? I suspect if I were an agent I reject most based upon the first few sentences.
Laer, IIRC you're a scientist.
Agents do what everyone, including you and I, do. That's why you have an abstract to begin a paper or poster: you can determine things like if you believe the writer knows their stuff, if it is a topic of interest to you, etc.....and just as I don't read an entire article on buckyballs or neutrinos and (I assume) you don't read an entire article on protein kinases in order to close with "yep, this is not my field of interest..." agents also skim looking for a match in things like interest, voice, talent, etc....
I don't say that to be argumentative or dickish, but to point out a very simple fact--it is easy to put agents on some mysterious pedestal, but they do the same sort of things you do every single day, and for the same reasons. You look at more articles, in Science and even in your local paper, than you read to end, and generally I'm sure they do too, for the same sort of reasons....