At what point do I cease seeking the views of others and stick to what I believe is the best presentation of the story I want to tell?

The piece is urban fantasy, 98,000 words, 414 pages, broken into sixty-four chapters.

I've had two solid beta readers: one loved it and had simply offered technical suggestions to keep the pace; the other keeps asking questions that will be answered in the following pages and is constantly referring to pov issues and how I'm breaking convention between third and omni. The typical friends' and family response is: couldn't put it down - read the last three-hundred pages in one sitting.

15 queries. 8 rejections.
2 requested fulls, one polite rejection within 4 days, one hanging for a month now.