I sent some queries to US agents over the two days before Thanksgiving. I wasn't thinking about the timing since I live in the UK (though I'm American and my book suits the US market).
Four days with zero responses is agonising! (I did get a handful on Wed., including two partial requests - yay!) (I was always an impatient person, and the Internet has only made it worse.)
Was it stupid to query the day before a holiday? Might it actually hurt me - i.e., will their inboxes be so full when they back to the office that they might be quicker to delete than usual?