Acknowledging an acknowledgment?

No. Resist the urge! They get a million emails to deal with. Do NOT give them a million and one with something completely irrelevant. I know it feels polite, but it's not, I swear.

Since it often means more to hear something from more than one person, I agree with WildScribe. Resist that urge!

Resist the urge and wait.

I responded to an agent once, but that's because they gave me some really good feedback on my query letter. I couldn't help myself.

But for what you said, I wouldn't respond. They already know you appreciate it.

katci13 said:

I responded to an agent once, but that's because they gave me some really good feedback on my query letter. I couldn't help myself.

But for what you said, I wouldn't respond. They already know you appreciate it.

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That I'd say is fine - recommended, even - because they've spent time they didn't have to.

Otherwise, no.

Sophie, that's probably still an auto-reply, just one which is sent once somebody has checked your submission has arrived intact. If I was given to speculation, it could be a system where all incoming queries are checked, a confirmation sent to the ones kept, and rejections sent to the people who've sent the wrong genre/slush pile hell candidates.