Okay, so on the panel today with Lucienne Diver, Tamora Pierce, and a couple of other people, there was some talk about things publishers are looking for. Of course, there's no way to know the next big thing, but this is what they said about what pubs (and they) want.
They're seeing publishers take more sci-fi, but they're being very selective
Lucienne Diver says mainstream, mystery, and suspense are getting big.
As I mentioned in the dystopia thread, it's not dead, but it's on it's way out. Paranormal romance is also not dead.
There was talk about more cultural themes or a greater worldview.
The panelists all wanted to see more strong heroines, particularly ones who are actually heroic. It probably comes as no surprise that Tamora Pierce is a big fan of female heroes, and she made a distinction between female MCs, of which we have so many in YA, and female heroes, which she feels we are lacking.
Oh, and two things that publishers don't like very much... Anti-heroes and unreliable narrators. Which makes me sad.