My experience with locating an agent/publisher was nightmarish the first time around. I shelved my first book and wrote a second.
Now I find I just don't have the stomach to face the inevitable rejection found in the traditional publishing route.
If my expectations for the success of this second, better, book are in line with reality (i.e. low sales, maybe 100 - 500 copies, mostly locally), is there any danger to traditional publishing aspirations on future books? Will poor sales through self-publishing haunt me afterwards?